Effects of Vitamin D Supplementation and Systemic Lupus Erythematosus Disease Activity


Asia Pacific Journal Paediatric and Child Health, Volume 3, Oct - Dec 2020

Effects of Vitamin D Supplementation and Systemic Lupus Erythematosus Disease Activity

Syahmi Amar1 , Annang Giri Moelyo1 , Diah Lintang Kawuryan1


Background: Systemic Lupus Erythematosus (SLE) patients tend to experience vitamin D deficiency in attribution to several factors. However, studies linking vitamin D levels and SLE disease activity in children are still lacking, particularly in Indonesia.

Objective: This study aims to analyze the effects of vitamin D supplementation on the activity of SLE among children.

Methods: This was a quasi-experimental study with a pre-post treatment test design in same group. A total of 20 pediatric patients with SLE at Dr. Moewardi Hospital who met the inclusion criteria were included in the study for a period of 3 months. Vitamin D levels were measured before and after vitamin D supplementation.

Results: A total of 18 pediatric patients with SLE were included in the final analyses with an average age of 14.1  2.53 years. Kidney and skin were the most commonly affected organs among the study participants. There was a significant difference in the average Mex-SLEDAI score before and after the intervention (p = 0.006). Vitamin D level correlated negatively with SLE disease activity prior to intervention (r = -0.616; p = 0.003). Increased vitamin D levels also correlated significantly with decreased SLE disease activity (r = -0.493; p = 0.044).

Limitations: The sample size was quite small as it was a single-center study and the subjects were not recruited in a random, doubleblind fashion.

Conclusions: There is a negative correlation between vitamin D levels and SLEDAI scores. Higher levels of vitamin D shall reduce the SLEDAI scores.

Keywords: SLE, SLEDAI, vitamin D.

Author’s Affiliation:
1- Department of Pediatrics, Dr Moewardi Hospital/Faculty of Medicine Sebelas Maret University, Surakarta, Indonesia

Syahmi Amar, Email: syahmiamar@gmail.com