Medicinski Glasnik (Zenica) Vol 23, No 1 (2026)
Stem cells and secretome in aplastic anaemia: a bibliometric analysis of global research trends (2018–2023) and future directions for regenerative therapies
Citra Primavita Mayangsari1,*, Harsono Salimo1 , Yulia Lanti Retno Dewi1 , Agung Putra2,3, Betty Suryawati1 , Annang Giri Moelyo4
1 Doctoral Program of Medical Science, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, 2 Stem Cell and Cancer Research (SCCR) Laboratory, Semarang, 3 Department of Doctoral Biomedical Science, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, 4 Department of Child Health, Faculty of Medicine, Universitas Sebelas Maret/Dr. Moewardi Hospital, Surakarta; Indonesia
ABSTRACT
Aim This study analysed research trends related to stem cells and secretome in aplastic anemia between 2018 and 2023 using a bibliometric approach to understand developments and research distribution in this field.
Methods The Scopus database was used to search for relevant articles on aplastic anaemia and its relationship to stem cells or secretome, collecting publication and citation data found in article titles, abstracts, and keywords. VOSviewer and Biblioshiny bibliometric software were used to visualize author, country, journal, and keyword networks. Visualization maps aimed to highlight the emergence of words and phrases in titles and abstracts.
Results Based on information from 1,405 articles identified from 2018 to 2023, publication numbers experienced significant fluctuations. Research showed that publications on aplastic anaemia, stem cells, or secretome increased by an average of 2.52% annually over the past five years. The most productive country was China with 321 documents, while the most productive institution was the Chinese Academy of Medical Sciences & Peking Union Medical College with 53 documents. We identified four cluster groups: “severe aplastic anaemia”, “allogeneic stem cell transplantation”, “bone marrow failure”, and “hematopoietic stem cell transplantation”.
Conclusion This study provides a comprehensive overview of research trends in aplastic anaemia related to stem cells and secretome from 2018 to 2023, highlighting steady growth and key contributors like China. Future research will likely focus on secretome applications and international collaborations to advance regenerative therapies for aplastic anaemia.
Keywords: aplastic anaemia, bibliometrics, secretome, stem cells, mesenchymal stem cells
*Corresponding author: Citra Primavita Mayangsari Doctoral Program of Medical Science, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Jl. Ir. Sutami 36A, Surakarta, Central Java, Indonesia Postcode: 57126 Phone: +62 271 664178 E-mail: citraprimavita@gmail.com ORCID ID: https://orcid.org/0009-0003-7121-1390 | Submitted: 22 Mar 2025. Revised: 15 Jul 2025. Accepted: 24 Aug 2025