CORRELATION BETWEEN SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX SCORE AND ANTI-MULLERIAN HORMONE LEVEL IN PEDIATRICS SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

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Asia Pacific Journal Paediatric and Child Health, Volume 3, Oct - Dec 2020

CORRELATION BETWEEN SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX SCORE AND ANTI-MULLERIAN HORMONE LEVEL IN PEDIATRICS SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

Hamid Pramusyahid1 , Diah Lintang Kawuryan1 , Sri Lilijanti Widjaja1 , Annang Giri Moelyo1

ABSTRACT

Background: Systemic lupus erythematosus disease activity index (SLEDAI) is a scoring system to assess the activity of systemic lupus erythematosus (SLE) disease. SLE patients are at risk of amenorrhea, which may lead to infertility. The anti-Müllerian hormone is used as a marker for infertility risk in females.

Aim: To analyze the correlation between systemic lupus erythematosus disease activity index score and the level of anti-Müllerian hormone (AMH) as a marker for infertility risk in pediatric SLE patients.

Methods: A cross-sectional study was conducted in 6-18 years old female patients with SLE admitted to the pediatric ward of dr. Moewardi General Hospital, Surakarta between December 2018–October 2019. The diagnosis of SLE was established based on systemic lupus international collaborating clinics (SLICC 2012) criteria. All subjects received SLEDAI scoring and anti-Müllerian hormone examination. The correlation between variables was analyzed using the Spearman rank test to determine the correlation coefficient and the p value of ≤ 0.05 was considered significant.

Results: Twenty-one female pediatric SLE patients were included in the study. The mean age of the subjects was 14 years old. There was a significant negative correlation between SLEDAI score and AMH level in pediatric SLE patients (r = -0.841; p-value < 0.0001).

Conclusion: In pediatric SLE patients SLEDAI score has a negative correlation with AMH level.

Keywords: SLE, SLEDAI, AMH, Pediatrics.

Author’s Affiliation: 1- Department of Pediatrics, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia

Correspondence: Hamid Pramusyahid, Email: hamidpediatri@gmail.com